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Originalarbeiten

2017

Richter A, Hollstein R, Hebert E, Vulinovic F, Eckhold J, Osmanovic A, Depping R, Kaiser FJ, Lohmann K

In-depth Characterization of the Homodimerization Domain of the Transcription Factor THAP1 and Dystonia-Causing Mutations Therein

J Mol Neurosci 10.1007/s 12031-017-0904-2, 2017 [Epub ahead of print]

 

Wolff M, Kosyna FK, Dunst J, Jelkmann W, Depping R

Impact of hypoxia inducible factors on estrogen receptor expression in breast cancer cells

Arch Biochem Biophys 613:23-30, 2017

2016

Kauffenstein G, Tamareille S, Prunier F, Roy C, Ayer A, Toutain B, Billaud M, Isakson BE, Grimaud L, Loufrani L, Rousseau P, Abraham P, Procaccio V, Monyer H, de Wit C, Boeynaems JM, Robaye B, Kwak BR, Henrion D

Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone

Arterioscler Thromb Vasc 36(8): 1598-606, 2016

 

Segura-Puimedon M, Mergia E, Al-Hasani J, Aherrahrou R, Stoelting S, Kremer F, Freyer J, Koesling D, Erdmann J, Schunkert H, de Wit C, Aherrahrou Z

Proatherosclerotic Effect of the alpha1-Subunit of Soluble Guanylyl Cyclase ba Promoting Smooth Muscle Phenotypic Switching

Am J Pathol 186(8): 2220-31, 2016

 

 

 

Mandl M, Lieberum MK, Depping R

A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT

Cell Death Dis 7(6): e2284, 2016

 

Kramer J, Schwanbeck R, Pagel H, Cakiroglu F, Rohwedel J, Just U

Inhibition of Notch Signaling Ameliorates Acute Kidney Failure and Downregulates Platelet-Derived Growth Factor Receptor ß in the Mouse Model

Cells Tissues Organs 201(2): 109-17, 2016

 

Cakiroglu F, Enders-Comberg SM, Pagel H, Rohwedel J, Lehnert H, Kramer J

Erythropoietin-enhanced endothelial progenitor cell recruitment in peripheral blood and renal vessels during experimental acute kidney injury in rats

Cell Biol Int 40(3): 298-307, 2016

2015

Gemoll T, Epping F, Heinrich L, Fritzsche B, Roblick UJ, Szymczak S, Hartwig S, Depping R, Bruch, HP, Thorns C, Lehr S, Paech A, Habermann JK

Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies

Oncotarget 6(18): 16517-26, 2015

 

Mandl M, Lieberum MK, Dunst J, Depping R

The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment

Radiation Oncology 10:229, 2015

 

Kosyna FK, Nagel M, Kluxen L, Kraushaar K, Depping R

The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways

Biol Chem pii: /j/bchm.ahead-of-print/hsz-2015-0171/hsz-2015-0171.xml [Epub ahead of print]

 

Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W

ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1

Circulation 131(13):1191-201, 2015

 

Schmidt VJ, Hilgert JG, Covi JM, Leibig N, Wietbrock JO, Arkudas A, Polykandriotis E, de Wit C

Flow increase is decisive to initiate angiogenesis in veins exposed to altered hemodynamics

PLoS One 10(1):e0117407, 2015

 

Schraivogel D, Schindler SG, Danner J, Kremmer E, Pfaff J, Hannus S, Depping R, Meister G

Importin-beta facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels

Nucleic Acids Res. 2015 Jul 13. pii: gkv705. [Epub ahead of print]

 

Sun W, Kosyna FK, Jelkmann W, Depping R

Prolyl-4-Hydroxylase 2 potentially contributes to hepatocellular carcinoma-associated Erythropoiesis by maintaining Hepatocyte Nuclear Factor-4α Expression

Cell Physiol Biochem 37:2257-2264, 2015

 

2014

 

Erogullari A, Hollstein R, Seibler P, Braunholz D, Koschmidder E, Depping R, Eckhold J, Lohnau T, Gillessen-Kaesbach G, Grünewald A, Rakovic A, Lohmann K, Kaiser FJ

THAP1, the gene mutated in DYT6 dystonia, autoregulates its own expression

Biochim Biophys Acta. 2014 Aug 1. pii: S1874-9399(14)00207-7. doi: 10.1016/j.bbagrm.2014.07.019. [Epub ahead of print]

 

Huegel, S, Depping R, Dittmar G, Rother F, Cabot R, Sury MD, Hartmann E, Bader M

Identification of importin alpha 7 specific transport cargoes using a proteomic screening approach

Mol Cell Proteomics, [Epub ahead of print], 2014

 

van Rahden VA, Rau I, Fuchs S, Kosyna FK, de Almeida HL Jr, Fryssira H, Isidor B, Jauch A, Joubert M, Lachmeijer AM, Zweier C, Moog U, Kutsche K
Clinical spectrum of females with HCCS mutation: from no clinical signs to a neonatal lethal form of the microphthalmia with linear skin defects (MLS) syndrome
Orphanet J Rare Dis 9(1):53 [Epub ahead of print], 2014

 

Sun W, Depping R, Jelkmann W

Interleukin-1β promotes hypoxia-induced apoptosis of
glioblastoma cells by inhibiting hypoxia-inducible
factor-1 mediated adrenomedullin production

Cell Death and Disease 5, e1020; doi:10.1038/cddis.2013.562, 2014

 

Sun W, Jelkmann W, Depping R

Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-?

Cell Death Dis. 2014 Jul 10;5:e1322. doi: 10.1038/cddis.2014.295

 

Thunemann M, Schmidt K, de Wit C, Han X, Jain RK, Fukumura D, Feil R

Correlative intravital imaging of cGMP signals and vasodilation in mice

Front Physiol 5:394, 2014

 

2013

 

Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser
FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf
E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I,
Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C,
Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li
SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U, Cardiogram,
Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H
Dysfunctional nitric oxide signalling increases risk of myocardial
infarction

Nature 540:432-436, 2013


Gey C, Seeger K
Metabolic changes during cellular senescence investigated by proton NMR-spectroscopy
Mech Ageing Dev 134(3-4):130-8, 2013

 

Günter CI, Bader A, Dornseifer U, Egert S, Sebastian D, Grieb G, Wolter T, Pallua N, von Wild T, Siemers F, Mailänder P, Thamm O, Ernert C, Steen M, Sievers R, Reichert B, Rahmanian-Schwarz A, Schaller H, Hartmann B, Otte M, Kehl V, Ohmann C, Jelkmann W, Machens HG

A multi-center study on the regenerative effects of erythropoietin in burn and scalding injuries: study protocol for a controlled trial

Trials 14(1): 124, 2013
 


Mallavia B, Recio C, Oguiza A, Ortiz-Muñoz G, Lazaro I, Lopez-Parra V, Lopez-Franco O, Schindler S, Depping R, Egido J, Gomez-Guerrero C.
Peptide Inhibitor of Nuclear Factor-κB Translocation Ameliorates Experimental Atherosclerosis
Am J Pathol 182(5):1910-21, 2013


Radtke J, Schmidt K, Wulff H, Köhler R, de Wit C
Activation of KCa3.1 by SKA-31 induces arteriolar dilation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice
Br J Pharmacol 170, 293-303,2013

Schmidt VJ, Hilgert JG, Covi JM, Weis C, de Wit C, Horch RE, Kneser U
High flow conditions increase connexin43 expression in a rat arteriovenous and angioinductive loop model

PLoS One 8:e78782, 2013

Thunemann M, Wen L, Hillenbrand M, Vachaviolos A, Feil S, Ott T, Han X,
Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R
Transgenic mice for cGMP imaging
Circ Res 113: 365-371, 2013


Wolff M, Jelkmann W, Dunst J, Depping R
The aryl hydrocarbon receptor nuclear translocator (ARNT/HIF-1β) is influenced by hypoxia and hypoxia-mimetics.
Cell Physiol Biochem
32(4):849-858 [Epub ahead of print], 2013


2012

von Brandenstein M, Schlosser M, Richter C, Depping R, Fries JW
ETS-dependent p16(INK4a) and p21(waf1/cip1) gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells
Life Sci 91(13-14): 562-71, 2012

Damkjaer M, Nielsen G, Bodendiek S, Staehr M, Gramsbergen JB, de Wit C, Jensen BL, Simonsen U, Bie P, Wulff H, Köhler R
Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarisation and lowers blood pressure in conscious dogs
Br J Pharmacol 165(1): 223-34, 2012

Depping R, Schindler SG, Jacobi C, Kirschner KM, Scholz H
Nuclear Transport of Wilms' Tumour Protein Wt1 Involves Importins alpha and beta
Cell Physiol Biochem 29(1-2): 223-32, 2012

Flöter N, Schmidt T, Keck A, Reer R, Jelkmann W, Braumann KM
Bestimmung der individuellen anaeroben Schwelle mittels der Herzfrequenzvariabilität in Abhängigkeit von der sympathoadrenergen Aktivität
Dtsch Z Sportmed 63(2): 41-45, 2012

Jobs A, Schmidt K, Schmidt VJ, Lübkemeier I, van Veen TAB, Kurtz A, Willecke K, de Wit C
Defective Cx40 maintains Cx37 expression but intact Cx40 is crucial for conducted dilations irrespective of hypertension
Hypertension 60: 1422-1429, 2012

Knuever J, Poeggeler B, Gáspár E, Klinger M, Hellig-Buergel T, Hardenbicker C, Tóth Bl, Biró T, Paus R
Thyrotropin-Releasing Hormone Controls Mitochondrial Biology in Human Epidermis
J Clin Endocrinol Metab 97(3):978-86, 2012

Nolde J, de Wit C, Gemoll T, Schloericke E, Bruch HP, Laubert T
Regulation of tumor growth and angiogenesis in colorectal cancer
Eur Surg 44(5): 336-340, 2012

Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Joehren O, Fandrey J, Berchner-Pfannschmidt U, Depping R
Oxygen sensing by Prolyl-4-Hydroxylase PHD2 within the nuclear compartment and the influence of compartimentalisation on HIF-1 signalling
J Cell Sci 125(21): 5168-5176, 2012

Schmidt VJ, Jobs A, von Maltzahn J, Wörsdörfer P, Willecke K, de Wit C
Connexin45 is expressed in vascular smooth muscle but its function remains elusive
PLoS One 7: e42287, 2012

Wang L, Yin J, Nickles H, Ranke H, Tabuchi A, Hoffmann J, Tabeling C, Barbosa-Sicard E, Chanson M, Kwak BR, Shin HS, Wu S, Isakson B, Witzenrath M, de Wit C, Fleming I, Kuppe H, Kuebler WM
Hypoxic pulmonary vasoconstriction requires endothelial signal conduction via connexin40
J Clin Invest 122: 4218-4230, 2012


2011

Böttcher M, de Wit C
Distinct EDHFs emerge in vitro and in vivo and are mediated in part via
connexin40-dependent myoendothelial coupling

Hypertension 57: 802-808, 2011

von Brandenstein M, Depping R, Schäfer E, Dienes HP, Fries JW
Protein kinase C a regulates nuclear pri-microRNA 15a release as a part of endothelin signaling
Biochim Biophys Acta 1813(10): 1793-802, 2011

Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E
The Function of Hypoxia-Inducible Factor (HIF) Is Independent of the Endoplasmic Reticulum Protein OS-9
Plos ONE, Volume 6: 4, 2011

Martrat G, et al.Exploring the link between MORF4L1 and risk of breast cancerBreast Cancer Res 13(2): R40, 2011

Ströfer M, Jelkmann W, Depping R
Curcumin Decreases Survival of Hep3B Liver and MCF-7 Breast Cancer Cells : The Role of HIF
Strahlenther Onkol 187(7): 393-400, 2011

Ströfer M, Jelkmann W, Metzen E, Brockmeier U, Dunst J, Depping R
Stabilisation and Knockdown of HIF - Two Distinct Ways Comparably Important in Radiotherapy
Cell Physiol Biochem 28:805-12, 2011


2010

Ao Z, Jayappa KD, Wang B, Zheng Y, Kung S, Rassart E, Depping R, Kohler M, Cohen EA,
Yao X
Importin {alpha}3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and
replication

J Virol 84: 8650-63, 2010

Babin-Ebell J, Sievers HH, Charitos EI, Klein HM, Jung F, Hellberg AK, Depping R, Sier HA, Marxsen J
Stoelting S, Kraatz EG, Wagner KF
Transmyocardial Laser Revascularization Combined with Intramyocardial Endothelial Progenitor Cell Transplantation in Patients with Intractable Ischemic Heart Disease Ineligible for Conventional Revascularization: Preliminary Results in a Highly Selected Small Patient Cohort
Thorac Cardiov Surg 58: 11-16, 2010

Bodo E, Wiersma F, Funk W, Kromminga A, Jelkmann W, Paus R
Does erythropoietin modulate human hair follicle melanocyte activities in situ?
Exp Dermatol 19: 65-67, 2010

Böttcher M, Gloe T, de Wit C
Semiautomatic quantification of angiogenesis.
J Surg Res 162: 132-139, 2010

Chadjichristos CE, Scheckenbach KEL, van Veen TAB, Sarieddine MZR, de Wit C, Yang Z, Roth I, Bacchetta M, Viswambharan H, Foglia B, Dudez T, van Kempen MJA, Coenjaerts FEJ, Miquerol L, Deutsch U, Jongsma HJ, Chanson M, Kwak BR
Endothelial-specific deletion of Cx40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion
Circulation 121: 123-131, 2010

de Wit C
Different pathways with distinct properties conduct dilations in the microcirculation in vivo.
Cardiovasc Res 85: 604-613, 2010

Huenniger K, Krämer A, Soom M, Chang I, Köhler M, Depping R, Kehlenbach RH, Kaether C.
Notch1 signaling is mediated by importins alpha 3, 4, and 7.
Cell Mol Life Sci 67: 3187-96, 2010

Milkau M, Köhler R, de Wit C
Crucial importance of the endothelial K+-channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction
FASEB J 24: 3572-3579, 2010

Roth A, König P, van Zandbergen G, Klinger M, Hellwig-Bürgel T, Däubener W, Bohlmann MK, Rupp J
Hypoxia abrogates antichlamydial properties of IFN-{gamma} in human fallopian tube cells in vitro and ex vivo
PNAS 107: 19502-7, 2010

Schmidt K, Dubrovska G, Nielsen G, Fesüs G, Uhrenholt TR, Lærkegaard-Hansen P, Gudermann T, Dietrich A, Gollasch M,de Wit C, Köhler R
Amplification of EDHF-type vasodilatations in TRPC1-deficient mice
Br J Pharmacol 161: 1722-1733, 2010

Steichen-Gersdorf E, Griesmaier E, Pientka FK, Kotzot D, Kutsche K
A severe form of the X-linked microphthalia with linear skin defects syndrome in a female newborn
Clin Dysmorphol 19: 82-4, 2010

Wagner C, Jobs A, Schweda F, Kurtz L, Kurt B, Sequeira-Lopez M, Gomez R, van Veen TAB, de Wit C, Kurtz A
Selective deletion of connexin40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension
Kidney Int 78: 762-8, 2010


2009

Ballal A, Saeed A, Rouina P, Jelkmann W
Effects of chloroquine treatment on circulating erythropoietin and inflammatory cytokines in acute Plasmodium falciparum malaria.
Ann Hematol 88: 411-5, 2009

Brähler S, Kaistha A, Schmidt VJ, Wölfle SE, Busch C, Kaistha BP, Kacik M, Hasenau AL, Grgic I, Si H, Bond CT, Adelman JP, Wulff H, de Wit C, Hoyer J, Köhler R
Genetic deficit of SK3 and IK1 channels disrupts the EDHF vasodilator pathway and causes hypertension.
Circulation 119: 2323-32, 2009

Groesdonk HV, Bauer A, Kreft B, Heringlake M, Paarmann H, Pagel H
Urodilatin and Pentoxifylline prevents the early onset of escherichia coli-induced acute renal failure in a model of isolated perfused rat kidney.
Kidney Blood Press Res 32: 81-90, 2009

Heinicke I, Böhler A, Rechsteiner T, Bogdanova A, Jelkmann W, Hofer M, Rawlings P, Araneda OF, Behn C, Gassmann M, Heinicke K
Moderate altitude but not additional endurance training increases markers of oxidative stress in exhaled breath condensate.
Eur J Appl Physiol 106: 599-604,2009

Just A, Kurtz L, de Wit C, Wagner C, Kurtz A, Arendshorst WJ
Connexin40 mediates tubuloglomerular feedback contribution to renal blood flow autoregulation
J Am Soc Nephrol 20: 1577-85, 2009

Schweda F, Kurtz L, de Wit C, Janssen-Bienhold U, Kurtz A, Wagner C
Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension.
Kidney Int 75: 482-9, 2009

Spanholtz T, Maichle A, Niedworok C, Stoeckelhuber BM, Krüger S, Wedel T, Aach T, Middeler G, Hellwig-Bürgel T, Bader A, Krengel S, Müller OJ, Franz WM, Lindenmaier W, Machens HG
Timing and targeting of cell-based VEGF165 gene expression in ischemic tissue.
J Surg Res 151: 153-62, 2009

Steinhoff A, Pientka FK, Möckel S, Kettelhake A, Hartmann E, Köhler M, Depping R
Cellular oxygen sensing: Importins and Exportins are mediators of intracellular localisation of Prolyl-4-Hydroxylases PHD1 and PHD2.
Biochem Biophys Res Commun 387: 705-11, 2009

Wölfle SE, Schmidt VJ, Hoyer J, Köhler R, de Wit C
Prominent role of KCa3.1 in EDHF-type dilations and conducted responses in the microcirculation in vivo.
Cardiovasc Res 82: 476-483, 2009

Wuelling M, Kaiser JF, Buelens LA, Braunholz D, Shivdasani RA, Depping R, Vortkamp A
Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3
Dev Biol 328: 40-53, 2009


2008

Aherrahrou Z, Doehring LC, Maria-Ehlers E, Liptau H, Depping R, Linsel-Nitschke P, Kaczmarek PM, Erdmann  J, Schunkert H
An alternative splice variant in ABCC6, the gene causing dystrophic calcification, leads to protein deficiency in C3H/He mice.
J Biol Chem. 283: 7608-15, 2008

Asimakopoulos B, Abu-Hassan D, Metzen E, Al-Hasani S, Diedrich K, Nikolettos N
The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection.
Fertil Steril 90: 60-4, 2008

Depping R, Steinhoff A, Schindler S, Friedrich B, Fagerlund R, Metzen E, Hartmann E, Köhler M
Nuclear translocation of hypoxia-inducible factors (HIFs): Involvement of the classical importin a/b pathway
Biochim Biophys Acta. 1783: 394-404, 2008

Hassouna I, Sperling S, Kim E, Schulz-Schaeffer W, Rave-Fränk M, Hasselblatt M, Jelkmann W, Giese A, Ehrenreich H
Erythropoietin augments survival of glioma cells after radiation and temozolomide.
Int J Radiat Oncol Biol Phys 72: 927-34, 2008

Laugsch M, Metzen E, Svensson T, Depping R, Jelkmann W
Lack of functional erythropoietin receptors of cancer cell lines.
Int J Cancer 122:1005-1011, 2008

Rantanen K, Pursiheimo J, Högel H, Himanen V, Metzen E, Jaakkola PM
Prolyl Hydroxylase PHD3 Activates Oxygen-dependent Protein Aggregation.
Mol Biol Cell 19: 2231-40, 2008

Schön MR, Hogrebe E, Hengstler JG, Donaubauer B, Faber SC, Bauer A, Pietsch UC, Jelkmann W, Thiery J, Hauss JP, Tannapfel A
Erythropoietin stimulates hepatocyte regeneration after liver resection.
Excli J 7: 79-92, 2008

von Brandenstein MG, Ngum Abety A, Depping R, Roth T, Koehler M, Dienes HP, Fries JW
A p38-p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells.
Biochim Biophys Acta 1783: 1613-1622, 2008

Wagner AE, Huck G, Stiehl DP, Jelkmann W, Hellwig-Bürgel T
Dexamethasone impairs hypoxia-inducible factor-1 function.
Biochem Biophys Res Commun 372: 336-40, 2008


2007

Österborg A, Aapro M, Cornes P, Haselbeck A, Hayward CRW, Jelkmann W

Preclinical studies of erythropoietin receptor expression in tumor cells: Impact on clinical use of erythropoietic proteins to correct cancer-related anaemia.
Eur J Cancer 43: 510-519, 2007

Bodo E, Kromminga A, Funk W, Laugsch M, Duske U, Jelkmann W, Paus R Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin
The Faseb J 21: 3346-54, 2007

Bohm J, Kaiser FJ, Borozdin W, Depping R, Kohlhase J
Synergistic cooperation of Sall4 and Cyclin D1 in transcriptional repression. Biochem Biophys Res Commun 356: 773-9, 2007

Heidbreder M, Qadri F, Jöhren O, Dendorfer A, Depping R; Fröhlich R, Wagner KF, Dominiak P
Non-hypoxic induction of HIF-3α by 2-deoxy-D-glucose and insulin.
Biochem Biophys Res Commun 352: 437-43, 2007

Krajewski J, Batmunkh C, Jelkmann W, Hellwig-Bürgel T
Interleukin-1beta inhibits the hypoxic inducibillity of the erythropoietin enhancer by suppressing hepatocyte nuclear factor-4alpha.
Cell Mol Life Sci 64: 989-98, 2007

Kurtz L, Schweda F, de Wit C, Kriz W, Witzgall R, Warth R, Sauter A, Kurtz A, Wagner C
Lack of connexin40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium.
J Am Soc Nephrol 18: 1103-1111, 2007


Rodenwaldt B, Pohl U, de Wit C
Endogenous and exogenous NO attenuates the conduction of vasoconstrictions along arterioles in the microcirculation.
Am J Physiol Heart Circ Physiol 292:H2341-8 Epub 2007


Wagner C, de Wit C, Gerl M, Kurtz A, Höcherl K
Increased expression of cyclooxygenase 2 contributes to aberrant
renin production in connexin40 deficient kidneys

Am J Physiol Regul Integr Comp Physiol 293:R1781-R1786, 2007

Wagner C, de Wit C, Kurtz L, Grünberger C, Kurtz A, Schweda F
Connexin40 is essential for the pressure control of renin synthesis and secretion.
Circ Res 100: 556-563, 2007

Wotzlaw C, Otto T, Berchner-Pfannschmidt U, Metzen E, Acker H, Fandrey J
Optical analysis of the HIF-1 complex in living cells by FRET and FRAP.
FASEB J 21: 700-7, 2007

Wölfle SE, Schmidt VJ, Hoepfl B, Gebert A, Alcoléa S, Gros D, de Wit C
Connexin45 (Cx45) cannot replace the function of Cx40 in conducting
endothelium-dependent dilations along arterioles.

Circ Res 101: 1292-1299, 2007


2006

Asimakopoulos B, Nikolettos N, Nehls B, Diedrich K, Al-Hasani S, Metzen E.
Gonadotropin-releasing hormone antagonists do not influence the secretion of steroid hormones but affect the secretion of vascular endothelial growth factor from human granulosa luteinized cell cultures.
Fertil Steril 86: 636-41, 2006

Batmunkh C, Krajewski J, Jelkmann W, Hellwig-Burgel T
Erythropoietin production: Molecular mechanisms of the antagonistic actions of cyclic adenosine monophosphate and interleukin-1.
FEBS Lett 580: 3153-60, 2006

Hubold C, Oltmanns KM, Schultes B, Jelkmann W, Born J, Fehm HL, Schweiger U, Peters A
High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetesInt.
J Obes (Lond) 30: 1356-61, 2006


Griesinger G, Dafopoulos K, Schultze-Mosgau A, Jelkmann W, von Otte S, Diesing D, Diedrich K
Vascular endothelial growth factor response to exogenous chorionic gonadotropic hormone in the luteal phase of women with a history of severe ovarian hyperstimulation syndrome.
Arch Gynecol Obstet 274: 29-33, 2006


Si H, Heyken WT, Wölfle SE, Tysiac M, Schubert R, Grgic I, Vilianovich L, Giebing G, Maier T, Gross V, Bader M, de Wit C, Hoyer J, Köhler R
Impaired EDHF-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+-channel
Circ Res 99: 537-544, 2006


2005

Brinckmann J, Kim S, Wu J, Reinhardt DP, Batmunkh C, Metzen E, Notbohm H, Bank RA, Krieg T, Hunzelmann N
Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
Matrix Biol 24: 459-68, 2005

 

Burmester H, Wolber EM, Freitag P, Fandrey J, Jelkmann W
Thrombopoietin production in wild-type and interleukin-6 knockout mice with acute inflammation.
J Interfer Cytokine Res 25: 407-413, 2005

 

Callapina M, Zhou J, Schnitzer S, Metzen E, Lohr C, Deitmer JW, Brüne B
Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation - implications for prolyl hydroxylase activity and iron.
Exp Cell Res 306:274-284, 2005

 

Dendorfer A, Heidbreder M, Hellwig-Bürgel T, Johren O, Qadri F, Dominiak P
Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals.
Free Radic Biol Med 38: 117-24, 2005

 

Depping R, Kawakami K, Ocker H, Wagner JM, Heringlake M, Noetzold A, Sievers HH, Wagner KF
Expression of the Erythropoietin Receptor in Human Heart.
J Thoracic and Carciovascular Surgery 130: 877-8, 2005

 

Depping R, Lohaus C, Meyer HE, Rüger W
The mono-ADP-ribosyltransferases Alt and ModB of bacteriophage T4: Target proteins identified.
Biochem Biophys Res Commun. 335: 1217-23, 2005

 

Doege K, Heine S, Jensen I, Jelkmann W, Metzen E
Inhibition of mitochondrial respiration elevates oxygen concentration, but leaves regulation of hypoxia-inducible factor (HIF) intact.
Blood 106: 2311-2317, 2005

 

Hellwig-Bürgel T, Stiehl D, Katschinski DM, Marxsen J, Kreft B, Jelkmann W
VEGF Production by Primary Human Renal Proximal Tubular Cells: Requirement of HIF-1, PI3-Kinase and MAPKK-1 Signaling.
Cell Physiol Biochem 15: 99-108, 2005

 

Hellwig-Bürgel T, Stiehl DP, Wagner AE, Metzen E, Jelkmann W
Hypoxia-inducible factor 1 (HIF-1): a novel transcription factor in immune reactions.
J Interfer Cytokine Res 25: 297-310, 2005

 

Martin F, Linden T, Katschinski DM, Oehme F, Flamme I, Mukhopadhyay CK, Eckhardt K, Troger J, Barth S, Camenisch G, Wenger RH
Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.
Blood 105: 4613-4619, 2005

 

Metzen E, Stiehl DP, Doege K, Marxsen JH, Hellwig-Bürgel T, Jelkmann W
Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element.
Biochem J 387: 711-7, 2005

 

Rupp J, Hellwig-Bürgel T, Wobbe V, Seitzer U, Brandt E, Maass M
Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo.
Proc Natl Acad Sci USA 102: 3447-3452, 2005

 

Siegl D, Koeppen M, Wölfle SE, Pohl U, de Wit C
Myoendothelial coupling is not prominent in arterioles within the mouse cremaster microcirculation in vivo.
Circ Res 97: 781-788, 2005

 

Vaupel P, Dunst J, Engert A, Fandrey J, Feyer P, Freund M, Jelkmann W
Effects of recombinant human erythropoietin (rHuEPO) on tumor control in patients with cancer-induced anemia.
Onkologie 28: 216-21, 2005

 

von Wussow U, Klaus J, Pagel H
Is the renal production of erythropoietin controlled by the brain stem?
Am J Physiol Endocrinol Metab 289: E82-E86, 2005

 

Wölfle SE, de Wit C
Intact endothelium-dependent dilation and conducted responses in resistance vessels of hypercholesterolemic mice in vivo.
J Vasc Res 42: 475-482, 2005

 



2004

 

Berchner-Pfannschmidt U, Petrat F, Doege K, Trinidad B, Freitag P, Metzen E, de Groot H, Fandrey J
Chelation of Cellular Calcium Modulates Hypoxia-inducible Gene Expression through Activation of Hypoxia-inducible Factor-1 {alpha}.
J Biol Chem 279: 44976-44986, 2004

 

Depping R, Hagele S, Wagner KF, Wiesner RJ, Camenisch G, Wenger RH, Katschinski DM
A dominant-negative isoform of hypoxia-inducible factor-1alpha specifically expressed in human testis.
Biol Reprod 71: 331-9, 2004

 

Drenkhahn M, Gescher DM, Wolber EM, Meyhoefer-Malik A, Malik E
Expression of angiopoietin 1 and 2 in ectopic endometrium on the chicken chorioallantoic membrane.
Fertil Steril 81: 869-75, 2004

 

Hasegawa J, Wagner KF, Karp D, Li D, Shibata J, Heringlake M, Bahlmann L, Depping R, Fandrey J, Schmucker P, Uhlig S
Altered pulmonary vascular reactivity in mice with excessive erythrocytosis.
Am J Respir Crit Care Med 169: 829-35, 2004

 

Heringlake M, Heide C, Bahlmann L, Eichler W, Pagel H, Schmucker P, Wergeland R, Armbruster FP, Klaus S
Effects of tilting and volume loading on plasma levels and urinary excretion of relaxin, NT-pro-ANP, and NT-pro-BNP in male volunteers.
J Appl Physiol 97: 173-9, 2004

 

Katschinski D, Le L, Schindler S, Thomas T, Voss A, Wenger R
Interaction of he PAS B Domain with HSP90 Accelerates Hypoxia-Inducible Factor-1alpha Stabilization.
Cell Physiol Biochem 14: 351-60, 2004

 

Koeppen M, Feil R, Siegl D, Feil S, Hofmann F, Pohl U, de Wit C
cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo.
Hypertension 44: 952-5, 2004

 

Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E
Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
Biochem J  381: 761-7, 2004

 

Perez de Lema G, Lucio-Cazana FJ, Molina A, Luckow B, Schmid H, de Wit C, Moreno-Manzano V, Banas B, Mampaso F, Schlöndorff D
Retinoic acid treatment protects MRL/lpr lupus mice from the development of glomerular disease.
Kidney Int 66: 1018-1028, 2004

 

Wagner KF, Hellberg AK, Balenger S, Depping R, Dodd-O J, Johns RA, Li D
Hypoxia-induced mitogenic factor has antiapoptotic action and is upregulated in the developing lung: coexpression with hypoxia-inducible factor-2alpha.
Am J Respir Cell Mol Biol 31: 276-82, 2004


2003

Dame C, Wolber EM, Freitag P, Hofmann D, Bartmann P, Fandrey J
Thrombopoietin gene expression in the developing human central nervous system.
Brain Res Dev Brain Res 143: 217-23, 2003

 

Gunga HC, Fries D, Humpeler E, Kirsch K, Boldt LE, Koralewski E, Johannes B, Klingler A, Mittermayr M, Rocker L, Yaban B, Behn C, Jelkmann W, Schobersberger W

Austrian Moderate Altitude Study (AMAS 2000) - fluid shifts, erythropoiesis, and angiogenesis in patients with metabolic syndrome at moderate altitude (congruent with 1700 m).

Eur J Appl Physiol 88: 497-505, 2003

 

Jabs WJ, Logering BA, Gerke P, Kreft B, Wolber EM, Klinger MH, Fricke L, Steinhoff J

The kidney as a second site of human C-reactive protein formation in vivo.

Eur J Immunol 33: 152-61, 2003

 

Katschinski DM, Marti HH, Wagner KF, Shibata J, Eckhardt K, Martin F, Depping R, Paasch U, Gassmann M, Ledermann B, Desbaillets I, Wenger RH
Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN.
Mol Cell Biol 23: 6780-6789, 2003

 

Klaus S, Heringlake M, Gliemroth J, Pagel H, Staubach K, Bahlmann L

Biochemical tissue monitoring during hypoxia and reoxygenation.

Resuscitation 56: 299-305, 2003

 

Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis.

FASEB J 17: 761-3, 2003

 

Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Bürgel T, Jelkmann W, Acker H, Fandrey J
Intracellular localisation of human HIF-1alpha hydroxylases: implications for oxygen sensing.
J Cell Sci 116: 1319-1326, 2003

 

Metzen E, Zhou J, Jelkmann W, Fandrey J, Brune B
Nitric Oxide Impairs Normoxic Degradation of HIF-1alpha by Inhibition of Prolyl Hydroxylases.
Mol Biol Cell 14: 3470-3481, 2003

 



2002

 

Dantz D, Bewersdorf J, Fruehwald-Schultes B, Kern W, Jelkmann W, Born J, Fehm HL, Peters A

Vascular endothelial growth factor: a novel endocrine defensive response to hypoglycemia.

J Clin Endocrinol Metab 87: 835-40, 2002

 

Hofer T, Wenger R H, Gassmann M 

Oxygen sensing, HIF-1a stabilization and potential therapeutic strategies.

Eur J Physiol 443: 503-507, 2002

 

Hopfl G, Wenger RH, Ziegler U, Stallmach T, Gardelle O, Achermann R, Wergin M, Kaser-Hotz B, Saunders HM, Williams KJ, Stratford IJ, Gassmann M, Desbaillets I

Rescue of Hypoxia-inducible Factor-1alpha-deficient Tumor Growth by Wild-Type Cells Is Independent of Vascular Endothelial Growth Factor.

Cancer Res 62: 2962-70, 2002

  

La Ferla K, Reimann C, Jelkmann J, Hellwig-Bürgel T

Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB.

FASEB J 16: 1811-3, 2002

 

Schmitt O, Schubert C, Feyerabend T, Hellwig-Bürgel T, Weiss C, Kühnel W
Preferential Topography of Proteins Regulating Vascularization and Apoptosis in a MX1 Xenotransplant After Treatment With Hypoxia, Hyperthermia, Ifosfamide, and Irradiation.

Am J Clin Oncol 25: 325-36, 2002

 

Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Bürgel T

Normoxic induction of the hypoxia-inducible factor 1a by insulin and interleukin-1ß involves the phosphatidylinositol 3-kinase pathway.

FEBS Lett 512: 157-162, 2002

 

Wolber EM, Haase B, Jelkmann W
Thrombopoietin Production in Human Hepatic Cell Cultures (HepG2) Is Resistant to IFN-alpha, IFN-ß, and IFN-gamma Treatment.
J Interfer Cytokine Res 22: 1185-1189, 2002