Originalarbeiten

2013

Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser
FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf
E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I,
Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C,
Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li
SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U, Cardiogram,
Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H
Dysfunctional nitric oxide signalling increases risk of myocardial
infarction

Nature 540:432-436, 2013


Radtke J, Schmidt K, Wulff H, Köhler R, de Wit C
Activation of KCa3.1 by SKA-31 induces arteriolar dilation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice
Br J Pharmacol 170, 293-303,2013

Schmidt VJ, Hilgert JG, Covi JM, Weis C, de Wit C, Horch RE, Kneser U
High flow conditions increase connexin43 expression in a rat arteriovenous and angioinductive loop model

PLoS One 8:e78782, 2013

 

Thunemann M, Wen L, Hillenbrand M, Vachaviolos A, Feil S, Ott T, Han X,
Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R
Transgenic mice for cGMP imaging
Circ Res 113: 365-371, 2013


2012

Damkjaer M, Nielsen G, Bodendiek S, Staehr M, Gramsbergen JB, de Wit C, Jensen BL, Simonsen U, Bie P, Wulff H, Köhler R
Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarisation and lowers bloodpressure in conscious dogs
Br J Pharmacol 165(1): 223-34, 2012

Jobs A, Schmidt K, Schmidt VJ, Lübkemeier I, van Veen TAB, Kurtz A, Willecke K, de Wit C
Defective Cx40 maintains Cx37 expression but intact Cx40 is crucial for conducted dilations irrespective of hypertension
Hypertension 60: 1422-1429, 2012

 

Nolde J, de Wit C, Gemoll T, Schloericke E, Bruch HP, Laubert T
Regulation of tumor growth and angiogenesis in colorectal cancer
Eur Surg 44(5): 336-340, 2012

 

Schmidt VJ, Jobs A, von Maltzahn J, Wörsdörfer P, Willecke K, de Wit C
Connexin45 is expressed in vascular smooth muscle but its function remains elusive
PLoS One 7: e42287, 2012

 

Wang L, Yin J, Nickles H, Ranke H, Tabuchi A, Hoffmann J, Tabeling C, Barbosa-Sicard E, Chanson M, Kwak BR, Shin HS, Wu S, Isakson B, Witzenrath M, de Wit C, Fleming I, Kuppe H, Kuebler WM
Hypoxic pulmonary vasoconstriction requires endothelial signal conduction via connexin40
J Clin Invest 122: 4218-4230, 2012


2011

Böttcher M, de Wit C
Distinct EDHFs emerge in vitro and in vivo and are mediated in part via connexin40-dependent myoendothelial coupling
Hypertension 57: 802-808, 2011


2010

Böttcher M, Gloe T, de Wit C
Semiautomatic quantification of angiogenesis.
J Surg Res 162: 132-139, 2010

Chadjichristos CE, Scheckenbach KEL, van Veen TAB, Sarieddine MZR, de Wit C, Yang Z, Roth I, Bacchetta M, Viswambharan H, Foglia B, Dudez T, van Kempen MJA, Coenjaerts FEJ, Miquerol L, Deutsch U, Jongsma HJ, Chanson M, Kwak BR
Endothelial-specific deletion of Cx40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion
Circulation 121: 123-131, 2010

de Wit C
Different pathways with distinct properties conduct dilations in the microcirculation in vivo.
Cardiovasc Res 85: 604-613, 2010

 

Milkau M, Köhler R, de Wit C
Crucial importance of the endothelial K+-channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction
FASEB J 24: 3572-3579, 2010

 

Schmidt K, Dubrovska G, Nielsen G, Fesüs G, Uhrenholt TR, Lærkegaard-Hansen P, Gudermann T, Dietrich A, Gollasch M, de Wit C, Köhler R
Amplification of EDHF-type vasodilatations in TRPC1-deficient mice
Br J Pharmacol 161: 1722-1733, 2010

 

Wagner C, Jobs A, Schweda F, Kurtz L, Kurt B, Sequeira-Lopez M, Gomez R, van Veen TAB, de Wit C, Kurtz A
Selective deletion of connexin40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension
Kidney Int 78: 762-8, 2010


2009

Brähler S, Kaistha A, Schmidt VJ, Wölfle SE, Busch C, Kaistha BP, Kacik M, Hasenau AL, Grgic I, Si H, Bond CT, Adelman JP, Wulff H, de Wit C, Hoyer J, Köhler R
Genetic deficit of SK3 and IK1 channels disrupts the EDHF vasodilator pathway and causes hypertension.
Circulation 119: 2323-32, 2009

 

Just A, Kurtz L, de Wit C, Wagner C, Kurtz A, Arendshorst WJ
Connexin40 mediates tubuloglomerular feedback contribution to renal blood flow autoregulation
J Am Soc Nephrol 20: 1577-85, 2009

 

Schweda F, Kurtz L, de Wit C, Janssen-Bienhold U, Kurtz A, Wagner C
Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension.
Kidney Int 75: 482-9, 2009

 

Wölfle SE, Schmidt VJ, Hoyer J, Köhler R, de Wit C
Prominent role of KCa3.1 in EDHF-type dilations and conducted responses in the microcirculation in vivo.
Cardiovasc Res 82: 476-483, 2009


2007

Kurtz L, Schweda F, de Wit C, Kriz W, Witzgall R, Warth R, Sauter A, Kurtz A, Wagner C
Lack of connexin40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium.
J Am Soc Nephrol 18: 1103-1111, 2007


Rodenwaldt B, Pohl U, de Wit C
Endogenous and exogenous NO attenuates the conduction of vasoconstrictions along arterioles in the microcirculation.
Am J Physiol Heart Circ Physiol 292:H2341-8 Epub 2007


Wagner C, de Wit C, Gerl M, Kurtz A, Höcherl K
Increased expression of cyclooxygenase 2 contributes to aberrant
renin production in connexin40 deficient kidneys

Am J Physiol Regul Integr Comp Physiol 293:R1781-R1786, 2007

 

Wagner C, de Wit C, Kurtz L, Grünberger C, Kurtz A, Schweda F
Connexin40 is essential for the pressure control of renin synthesis and secretion.
Circ Res 100: 556-563, 2007


Wölfle SE, Schmidt VJ, Hoepfl B, Gebert A, Alcoléa S, Gros D, de Wit C
Connexin45 (Cx45) cannot replace the function of Cx40 in conducting
endothelium-dependent dilations along arterioles.

Circ Res 101: 1292-1299, 2007


2006

Si H, Heyken WT, Wölfle SE, Tysiac M, Schubert R, Grgic I, Vilianovich L, Giebing G, Maier T, Gross V, Bader M, de Wit C, Hoyer J, Köhler R
Impaired EDHF-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+-channel
Circ Res 99: 537-544, 2006


2005

Siegl D, Koeppen M, Wölfle SE, Pohl U, de Wit C
Myoendothelial coupling is not prominent in arterioles within the mouse cremaster microcirculation in vivo.
Circ Res 97: 781-788, 2005

 

 

Wölfle SE, de Wit C
Intact endothelium-dependent dilation and conducted responses in resistance vessels of hypercholesterolemic mice in vivo.
J Vasc Res 42: 475-482, 2005

 



2004

 

Koeppen M, Feil R, Siegl D, Feil S, Hofmann F, Pohl U, de Wit C
cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo.
Hypertension 44: 952-5, 2004

 

 

Perez de Lema G, Lucio-Cazana FJ, Molina A, Luckow B, Schmid H, de Wit C, Moreno-Manzano V, Banas B, Mampaso F, Schlöndorff D
Retinoic acid treatment protects MRL/lpr lupus mice from the development of glomerular disease.
Kidney Int 66: 1018-1028, 2004


 

2003


Perez de Lema G, de Wit C, Cohen CD, Nieto E, Molina A, Banas B, Luckow B, Vicente AB, Mampaso F, Schlöndorff D
Angiotensin inhibition reduces glomerular damage and renal chemokine expression in MRL/lpr mice.
J Pharmacol Exp Ther 307: 275-281, 2003


de Wit C, Roos F, Bolz SS, Pohl U
Lack of vascular connexin40 is associated with hypertension and irregular arteriolar  vasomotion.
Physiol Genomics 13: 169-177, 2003


Bolz SS, Vogel L, Sollinger D, Derwand R, de Wit C, Loirand G, Pohl U
Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway.
Circulation 107: 3081-3087, 2003


Krötz F, de Wit C, Sohn HY, Zahler S, Gloe T, Pohl U, Plank C
Magnetofection - a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo.
Mol Ther 7: 700-710, 2003



2002

Hoepfl B, Rodenwaldt B, Pohl U, de Wit C
EDHF, but not NO or prostaglandins, is critical to evoke a conducted dilation upon ACh in hamster arterioles.
Am J Physiol 283: H996-H1004, 2002



2001

Theis M, de Wit C, Schlaeger TM, Eckardt D, Krüger O, Döring B, Risau W, Deutsch U, Pohl U, Willecke K
Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene.
Genesis 29: 1-13, 2001



2000

Ruschitzka FT, Wenger RH, Stallmach T, Quaschning T, de Wit C, Wagner K, Labugger R, Kelm M, Noll G, Rülicke T, Shaw S, Lindberg RL, Rodenwaldt B, Lutz H, Bauer C, Lüscher TF, Gassmann M
Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin.
Proc Natl Acad Sci USA 97: 11609-11613, 2000


Bolz SS, Galle J, Derwand R, de Wit C, Pohl U
OxLDL increase the sensitivity of the contractile apparatus in isolated resistance arteries for Ca2+ via a Rho- and Rho-kinase-dependent mechanism.
Circulation  102: 2402-2410, 2000


Bolz SS, Pieperhoff S, de Wit C, Pohl U
Intact endothelial and smooth muscle function in small skeletal muscle resistance arteries after 48h in vessel culture.
Am J Physiol 279: H1434-H1439, 2000


de Wit C, Roos F, Bolz SS, Kirchhoff S, Krüger O, Willecke K, Pohl U
Impaired conduction of vasodilations along arterioles in connexin40 deficient mice.
Circ Res 86: 649-655, 2000


Pohl U, de Wit C, Gloe T
Large arterioles in the control of blood flow: role of endothelium-dependent dilation.
Acta Physiol Scand  168: 505-510, 2000


Bolz SS, Pieperhoff S, de Wit C, Pohl U
Chronic increases in transmural pressure reduce NO mediated dilations in isolated resistance arteries of the hamster.
Acta Physiol Scand  168: 113-117, 2000


Bolz SS, Fisslthaler B, Pieperhoff S, de Wit C, Fleming I, Busse R, Pohl U
Antisense oligonucleotides against cytochrome P450 2C8 attenuate EDHF-mediated Ca2+ changes and dilation in isolated resistance arteries.
FASEB J 14: 255-260, 2000



1999

Bolz SS, de Wit C, Pohl U
Endothelium-dependent hyperpolarising factor but not NO reduces smooth muscle Ca2+ during acetylcholine-induced dilation of microvessels.
Br J Pharmacol 128: 124-134, 1999


de Wit C, Esser N, Lehr HA, Bolz SS, Pohl U
A pentobarbital sensitive EDHF comediates ACh-induced arteriolar dilation in the hamster microcirculation.
Am J Physiol 276: H1527-H1534, 1999



1998

de Wit C, Bolz SS, Kaas J, Pohl U
Myogenic effects enhance norepinephrine constriction: Inhibition by nitric oxide and felodipine.
Kidney Int 54 (Suppl. 67): S122-S126, 1998


de Wit C, Jahrbeck B, Schäfer C, Bolz SS, Pohl U
Nitric oxide opposes myogenic pressure responses predominantly in large arterioles in vivo.
Hypertension 31: 787-794, 1998



1997

de Wit C, Schäfer C, von Bismarck P, Bolz SS, Pohl U
Elevation of plasma viscosity induces sustained NO-mediated dilation in the hamster cremaster microcirculation in vivo.
Pflügers Arch 434: 354-361, 1997



1994

de Wit C, von Bismarck P, Pohl U
Synergistic action of vasodilators that increase cGMP and cAMP in the hamster cremaster microcirculation.
Cardiovasc Res 28: 1513-1518, 1994



1993

de Wit C, von Bismarck P, Pohl U
Mediator role of prostaglandins in acetylcholine-induced vasodilation and control of resting vascular diameter in the hamster cremaster microcirculation in vivo.
J Vasc Res 30: 272-278, 1993