2013Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser
FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf
E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I,
Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C,
Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li
SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U, Cardiogram,
Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H
Dysfunctional nitric oxide signalling increases risk of myocardial
infarction
Nature 540:432-436, 2013
Radtke J, Schmidt K, Wulff H, Köhler R, de Wit C
Activation of KCa3.1 by SKA-31 induces arteriolar dilation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice
Br J Pharmacol 170, 293-303,2013
 Schmidt VJ, Hilgert JG, Covi JM, Weis C, de Wit C, Horch RE, Kneser U
High flow conditions increase connexin43 expression in a rat arteriovenous and angioinductive loop model
PLoS One 8:e78782, 2013
Thunemann M, Wen L, Hillenbrand M, Vachaviolos A, Feil S, Ott T, Han X,
Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R
Transgenic mice for cGMP imaging
Circ Res 113: 365-371, 2013
2012Damkjaer M, Nielsen G, Bodendiek S, Staehr M, Gramsbergen JB, de Wit C, Jensen BL, Simonsen U, Bie P, Wulff H, Köhler R
Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarisation and lowers bloodpressure in conscious dogs
Br J Pharmacol 165(1): 223-34, 2012
Jobs A, Schmidt K, Schmidt VJ, Lübkemeier I, van Veen TAB, Kurtz A, Willecke K, de Wit C
Defective Cx40 maintains Cx37 expression but intact Cx40 is crucial for conducted dilations irrespective of hypertension
Hypertension 60: 1422-1429, 2012
 Nolde J, de Wit C, Gemoll T, Schloericke E, Bruch HP, Laubert T
Regulation of tumor growth and angiogenesis in colorectal cancer
Eur Surg 44(5): 336-340, 2012 Schmidt VJ, Jobs A, von Maltzahn J, Wörsdörfer P, Willecke K, de Wit C
Connexin45 is expressed in vascular smooth muscle but its function remains elusive
PLoS One 7: e42287, 2012
Wang L, Yin J, Nickles H, Ranke H, Tabuchi A, Hoffmann J, Tabeling C, Barbosa-Sicard E, Chanson M, Kwak BR, Shin HS, Wu S, Isakson B, Witzenrath M, de Wit C, Fleming I, Kuppe H, Kuebler WM
Hypoxic pulmonary vasoconstriction requires endothelial signal conduction via connexin40
J Clin Invest 122: 4218-4230, 2012
2011Böttcher M, de Wit C
Distinct EDHFs emerge in vitro and in vivo and are mediated in part via connexin40-dependent myoendothelial coupling
Hypertension 57: 802-808, 2011
2010Böttcher M, Gloe T, de Wit C
Semiautomatic quantification of angiogenesis.
J Surg Res 162: 132-139, 2010
 Chadjichristos CE, Scheckenbach KEL, van Veen TAB, Sarieddine MZR, de Wit C, Yang Z, Roth I, Bacchetta M, Viswambharan H, Foglia B, Dudez T, van Kempen MJA, Coenjaerts FEJ, Miquerol L, Deutsch U, Jongsma HJ, Chanson M, Kwak BR
Endothelial-specific deletion of Cx40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion
Circulation 121: 123-131, 2010
 de Wit C
Different pathways with distinct properties conduct dilations in the microcirculation in vivo.
Cardiovasc Res 85: 604-613, 2010
 Milkau M, Köhler R, de Wit C
Crucial importance of the endothelial K+-channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction
FASEB J 24: 3572-3579, 2010
 Schmidt K, Dubrovska G, Nielsen G, Fesüs G, Uhrenholt TR, Lærkegaard-Hansen P, Gudermann T, Dietrich A, Gollasch M, de Wit C, Köhler R
Amplification of EDHF-type vasodilatations in TRPC1-deficient mice
Br J Pharmacol 161: 1722-1733, 2010
 Wagner C, Jobs A, Schweda F, Kurtz L, Kurt B, Sequeira-Lopez M, Gomez R, van Veen TAB, de Wit C, Kurtz A
Selective deletion of connexin40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension
Kidney Int 78: 762-8, 2010
2009Brähler S, Kaistha A, Schmidt VJ, Wölfle SE, Busch C, Kaistha BP, Kacik M, Hasenau AL, Grgic I, Si H, Bond CT, Adelman JP, Wulff H, de Wit C, Hoyer J, Köhler R
Genetic deficit of SK3 and IK1 channels disrupts the EDHF vasodilator pathway and causes hypertension.
Circulation 119: 2323-32, 2009
 Just A, Kurtz L, de Wit C, Wagner C, Kurtz A, Arendshorst WJ
Connexin40 mediates tubuloglomerular feedback contribution to renal blood flow autoregulation
J Am Soc Nephrol 20: 1577-85, 2009
 Schweda F, Kurtz L, de Wit C, Janssen-Bienhold U, Kurtz A, Wagner C
Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension.
Kidney Int 75: 482-9, 2009
 Wölfle SE, Schmidt VJ, Hoyer J, Köhler R, de Wit C
Prominent role of KCa3.1 in EDHF-type dilations and conducted responses in the microcirculation in vivo.
Cardiovasc Res 82: 476-483, 2009
2007Kurtz L, Schweda F, de Wit C, Kriz W, Witzgall R, Warth R, Sauter A, Kurtz A, Wagner C
Lack of connexin40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium.
J Am Soc Nephrol 18: 1103-1111, 2007
Rodenwaldt B, Pohl U, de Wit C
Endogenous and exogenous NO attenuates the conduction of vasoconstrictions along arterioles in the microcirculation.
Am J Physiol Heart Circ Physiol 292:H2341-8 Epub 2007
Wagner C, de Wit C, Gerl M, Kurtz A, Höcherl K
Increased expression of cyclooxygenase 2 contributes to aberrant renin production in connexin40 deficient kidneys
Am J Physiol Regul Integr Comp Physiol 293:R1781-R1786, 2007
 Wagner C, de Wit C, Kurtz L, Grünberger C, Kurtz A, Schweda F
Connexin40 is essential for the pressure control of renin synthesis and secretion.
Circ Res 100: 556-563, 2007
Wölfle SE, Schmidt VJ, Hoepfl B, Gebert A, Alcoléa S, Gros D, de Wit C
Connexin45 (Cx45) cannot replace the function of Cx40 in conducting endothelium-dependent dilations along arterioles.
Circ Res 101: 1292-1299, 2007
2006Si H, Heyken WT, Wölfle SE, Tysiac M, Schubert R, Grgic I, Vilianovich L, Giebing G, Maier T, Gross V, Bader M, de Wit C, Hoyer J, Köhler R
Impaired EDHF-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+-channel
Circ Res 99: 537-544, 2006
2005 Siegl D, Koeppen M, Wölfle SE, Pohl U, de Wit C
Myoendothelial coupling is not prominent in arterioles within the mouse cremaster microcirculation in vivo.
Circ Res 97: 781-788, 2005
 Wölfle SE, de Wit C
Intact endothelium-dependent dilation and conducted responses in resistance vessels of hypercholesterolemic mice in vivo.
J Vasc Res 42: 475-482, 2005
2004
Koeppen M, Feil R, Siegl D, Feil S, Hofmann F, Pohl U, de Wit C
cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo.
Hypertension 44: 952-5, 2004
 Perez de Lema G, Lucio-Cazana FJ, Molina A, Luckow B, Schmid H, de Wit C, Moreno-Manzano V, Banas B, Mampaso F, Schlöndorff D
Retinoic acid treatment protects MRL/lpr lupus mice from the development of glomerular disease.
Kidney Int 66: 1018-1028, 2004 
2003
Perez de Lema G, de Wit C, Cohen CD, Nieto E, Molina A, Banas B, Luckow B, Vicente AB, Mampaso F, Schlöndorff D
Angiotensin inhibition reduces glomerular damage and renal chemokine expression in MRL/lpr mice.
J Pharmacol Exp Ther 307: 275-281, 2003
de Wit C, Roos F, Bolz SS, Pohl U
Lack of vascular connexin40 is associated with hypertension and irregular arteriolar vasomotion.
Physiol Genomics 13: 169-177, 2003
Bolz SS, Vogel L, Sollinger D, Derwand R, de Wit C, Loirand G, Pohl U
Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway.
Circulation 107: 3081-3087, 2003
Krötz F, de Wit C, Sohn HY, Zahler S, Gloe T, Pohl U, Plank C
Magnetofection - a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo.
Mol Ther 7: 700-710, 2003
2002Hoepfl B, Rodenwaldt B, Pohl U, de Wit C
EDHF, but not NO or prostaglandins, is critical to evoke a conducted dilation upon ACh in hamster arterioles.
Am J Physiol 283: H996-H1004, 2002
2001Theis M, de Wit C, Schlaeger TM, Eckardt D, Krüger O, Döring B, Risau W, Deutsch U, Pohl U, Willecke K
Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene.
Genesis 29: 1-13, 2001
2000Ruschitzka FT, Wenger RH, Stallmach T, Quaschning T, de Wit C, Wagner K, Labugger R, Kelm M, Noll G, Rülicke T, Shaw S, Lindberg RL, Rodenwaldt B, Lutz H, Bauer C, Lüscher TF, Gassmann M
Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin.
Proc Natl Acad Sci USA 97: 11609-11613, 2000
Bolz SS, Galle J, Derwand R, de Wit C, Pohl U
OxLDL increase the sensitivity of the contractile apparatus in isolated resistance arteries for Ca2+ via a Rho- and Rho-kinase-dependent mechanism.
Circulation 102: 2402-2410, 2000
Bolz SS, Pieperhoff S, de Wit C, Pohl U
Intact endothelial and smooth muscle function in small skeletal muscle resistance arteries after 48h in vessel culture.
Am J Physiol 279: H1434-H1439, 2000
de Wit C, Roos F, Bolz SS, Kirchhoff S, Krüger O, Willecke K, Pohl U
Impaired conduction of vasodilations along arterioles in connexin40 deficient mice.
Circ Res 86: 649-655, 2000
Pohl U, de Wit C, Gloe T
Large arterioles in the control of blood flow: role of endothelium-dependent dilation.
Acta Physiol Scand 168: 505-510, 2000
Bolz SS, Pieperhoff S, de Wit C, Pohl U
Chronic increases in transmural pressure reduce NO mediated dilations in isolated resistance arteries of the hamster.
Acta Physiol Scand 168: 113-117, 2000
Bolz SS, Fisslthaler B, Pieperhoff S, de Wit C, Fleming I, Busse R, Pohl U
Antisense oligonucleotides against cytochrome P450 2C8 attenuate EDHF-mediated Ca2+ changes and dilation in isolated resistance arteries.
FASEB J 14: 255-260, 2000
1999Bolz SS, de Wit C, Pohl U
Endothelium-dependent hyperpolarising factor but not NO reduces smooth muscle Ca2+ during acetylcholine-induced dilation of microvessels.
Br J Pharmacol 128: 124-134, 1999
de Wit C, Esser N, Lehr HA, Bolz SS, Pohl U
A pentobarbital sensitive EDHF comediates ACh-induced arteriolar dilation in the hamster microcirculation.
Am J Physiol 276: H1527-H1534, 1999
1998de Wit C, Bolz SS, Kaas J, Pohl U
Myogenic effects enhance norepinephrine constriction: Inhibition by nitric oxide and felodipine.
Kidney Int 54 (Suppl. 67): S122-S126, 1998
de Wit C, Jahrbeck B, Schäfer C, Bolz SS, Pohl U
Nitric oxide opposes myogenic pressure responses predominantly in large arterioles in vivo.
Hypertension 31: 787-794, 1998
1997de Wit C, Schäfer C, von Bismarck P, Bolz SS, Pohl U
Elevation of plasma viscosity induces sustained NO-mediated dilation in the hamster cremaster microcirculation in vivo.
Pflügers Arch 434: 354-361, 1997
1994de Wit C, von Bismarck P, Pohl U
Synergistic action of vasodilators that increase cGMP and cAMP in the hamster cremaster microcirculation.
Cardiovasc Res 28: 1513-1518, 1994
1993de Wit C, von Bismarck P, Pohl U
Mediator role of prostaglandins in acetylcholine-induced vasodilation and control of resting vascular diameter in the hamster cremaster microcirculation in vivo.
J Vasc Res 30: 272-278, 1993
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